Pembro + Lenva Safety Framework Live
4-trial validated IO+TKI toxicity predictor with v2.3 calculator, multi-combo comparator, 5 attribution decision trees, RWE calibration, and Supabase comments. The framework's discovery that population fragility (5×) dominates dose and DDI.
→Pembro + Lenva Efficacy Framework Draft
Companion ORR/PFS/OS predictor using max-of-arms × synergy logic. Reproduces LEAP-002 negative trial after post-hoc s 0.30 → 0.10 correction. 5 response-pattern decision trees.
→4DMT Capsid Pipeline Integration Draft
End-to-end pipeline test on engineered 4D-R100 (745aa, BBB 0.427) and 4D-C102 (739aa, BBB 0.292). 3 clinical trials integrated. Demonstrates the platform on engineered, not natural, capsids.
→Reprogramming Intelligence Study Draft
9 work packages plus final synthesis. 22 small-molecule chemical inducers scored, 9 competitor pipelines mapped, KAT8 / H4K16 activator gap surfaced as headline white space. Retina-first OSK rejuvenation recommended; AI-native discovery methodology paper drafted. Executive Scorecard with letter grades A–F.
→Adjacent deployment.
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