Heart Failure — Pipeline

The premise

The mechanism we're betting on.

Mechanism-stratified HFpEF / HFrEF protocol. Mitochondrial, fibrosis, and neurohormonal axes. NT-proBNP and 6-minute walk endpoints with echo-strain imaging secondary. The full mechanism map — including compound list, dose escalation, pre-specified biomarker thresholds, and the cross-walk modifiers used when re-fitting blends from related indications — is part of the gated methodology pack.Gated

RWE — real-world public landscape

What the rest of the world is doing.

Numbers below are surfaced by Atlas Bio's ClinicalTrials.gov and PubMed RWE pipelines, run against the Heart Failure indication. Counts are industry-wide trials registered on ClinicalTrials.gov, not Atlas Bio studies. Methodology →

RWE refreshed 2026-05-12

Phase I (B1/B2)

200

trials

Phase II (B3)

200

trials

Phase III (B4)

200

trials

Phase IV (B5)

200

trials

Top public trials by enrollment

NCT03473223 · Study to Investigate CSL112 in Subjects With Acute Coronary Syndrome · CSL Behring · n=18,226 · PHASE3 · COMPLETED

NCT00475852 · A Study Testing the Effectiveness of Nesiritide in Patients With Acute Decompensated Heart Failure · Scios, Inc. · n=7,141 · PHASE3 · COMPLETED

NCT00853658 · Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbidity-mortality in Patients With Chronic Heart Failure · Novartis Pharmaceuticals · n=7,064 · PHASE3 · COMPLETED

Recent published clinical evidence

Dapagliflozin in Patients Hospitalized for Heart Failure: Primary Results of the DAPA ACT HF-TIMI 68 Randomized Clinical Trial and Meta-Analysis of Sodium-Gluco · PMID 40884036 · Circulation · 2025
Comparison of diaphragmatic breathing exercises and incentive spirometry on the functional status of heart failure patients: a randomized controlled trial. · PMID 39794689 · BMC cardiovascular disorders · 2025
The STICH trial (Surgical Treatment for Ischemic Heart Failure): mode-of-death results. · PMID 24621972 · JACC. Heart failure · 2013

Pre-registered predictions

Locked before readout.

Predictions for this study are SHA-256 locked before any readout. Pre-registration covers target engagement, primary endpoint, secondary endpoints, and the falsification criterion. The hash, prediction wording, and timestamp are available to verified clinicians and indication researchers on request.Gated

Methodology pillars used

Same stack, every indication.

M2 · Pre-Registration — SHA-256 locking before readout.
M1 · IBC Reasoning — 19-agent audit (11 core + 8 reasoning nodes).
M3 · Cross-Trial Validation — mechanism-anchored bridging across indications.
M4 · RWE Pipelines — ClinicalTrials.gov, PubMed, FDA, EDGAR feeds (the source of the numbers above).

Want the full Heart Failure protocol?

The abstract above is open. Compound lists, dose escalations, SHA-256-locked prediction documents, agent-network reasoning chains, and trial design specifics are available to verified clinicians, indication researchers, and sponsors under MNDA. Contact management to begin the access request.

Contact management →