Pain Disorders — Pipeline

The premise

The mechanism we're betting on.

Chronic pain spanning neuropathic, inflammatory, and central-sensitisation phenotypes. Mechanism-anchored phenotype-to-treatment mapping. PROMIS pain primary, inflammatory and HRV biomarkers as secondary. The full mechanism map — including compound list, dose escalation, pre-specified biomarker thresholds, and the cross-walk modifiers used when re-fitting blends from related indications — is part of the gated methodology pack.Gated

RWE — real-world public landscape

What the rest of the world is doing.

Numbers below are surfaced by Atlas Bio's ClinicalTrials.gov and PubMed RWE pipelines, run against the Pain Disorders indication. Counts are industry-wide trials registered on ClinicalTrials.gov, not Atlas Bio studies. Methodology →

RWE refreshed 2026-05-12

Phase I (B1/B2)

200

trials

Phase II (B3)

200

trials

Phase III (B4)

200

trials

Phase IV (B5)

200

trials

Top public trials by enrollment

NCT05072314 · Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial · Monash University · n=4,300 · PHASE3 · RECRUITING

NCT00725127 · Chronotherapy with Low-dose Aspirin for Primary Prevention · University of Vigo · n=3,200 · PHASE4 · ACTIVE_NOT_RECRUITING

NCT02528188 · Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee · Pfizer · n=3,021 · PHASE3 · COMPLETED

Recent published clinical evidence

Effect of exercise and manual therapy or kinesiotaping on sEMG and pain perception in chronic low back pain: a randomized trial. · PMID 39054514 · BMC musculoskeletal disorders · 2024
Psychological and neurological predictors of acupuncture effect in patients with chronic pain: a randomized controlled neuroimaging trial. · PMID 36602299 · Pain · 2023
Pain neuroscience education and motor imagery-based exercise protocol for patients with fibromyalgia: A randomized controlled trial. · PMID 39262170 · Brain and behavior · 2024

Pre-registered predictions

Locked before readout.

Predictions for this study are SHA-256 locked before any readout. Pre-registration covers target engagement, primary endpoint, secondary endpoints, and the falsification criterion. The hash, prediction wording, and timestamp are available to verified clinicians and indication researchers on request.Gated

Methodology pillars used

Same stack, every indication.

M2 · Pre-Registration — SHA-256 locking before readout.
M1 · IBC Reasoning — 19-agent audit (11 core + 8 reasoning nodes).
M3 · Cross-Trial Validation — mechanism-anchored bridging across indications.
M4 · RWE Pipelines — ClinicalTrials.gov, PubMed, FDA, EDGAR feeds (the source of the numbers above).

Want the full Pain Disorders protocol?

The abstract above is open. Compound lists, dose escalations, SHA-256-locked prediction documents, agent-network reasoning chains, and trial design specifics are available to verified clinicians, indication researchers, and sponsors under MNDA. Contact management to begin the access request.

Contact management →