Vagus Nerve (VNS) — Pipeline

The premise

The mechanism we're betting on.

Non-invasive vagal stimulation combined with the inflammation- and HRV-active compound stack. Closed-loop HRV-guided dosing protocol with arrhythmia and inflammatory markers as guardrails. The full mechanism map — including compound list, dose escalation, pre-specified biomarker thresholds, and the cross-walk modifiers used when re-fitting blends from related indications — is part of the gated methodology pack.Gated

RWE — real-world public landscape

What the rest of the world is doing.

Numbers below are surfaced by Atlas Bio's ClinicalTrials.gov and PubMed RWE pipelines, run against the Vagus Nerve (VNS) indication. Counts are industry-wide trials registered on ClinicalTrials.gov, not Atlas Bio studies. Methodology →

RWE refreshed 2026-05-12

Phase I (B1/B2)

trials

Phase II (B3)

trials

Phase III (B4)

trials

Phase IV (B5)

trials

Top public trials by enrollment

NCT00215215 · Effectiveness Study Comparing Treatment With Drug(s) or Adjunctive VNS Therapy for Pharmacoresistant Partial Seizures · Cyberonics, Inc. · n=360 · PHASE4 · TERMINATED

NCT04539964 · Vagus Nerve Stimulation for Moderate to Severe Rheumatoid Arthritis · SetPoint Medical Corporation · n=243 · PHASE3 · ACTIVE_NOT_RECRUITING

NCT07487818 · A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation · Mayo Clinic · n=150 · PHASE2/PHASE3 · NOT_YET_RECRUITING

Recent published clinical evidence

Transcutaneous Auricular Vagus Nerve Stimulation for Chronic Insomnia Disorder: A Randomized Clinical Trial. · PMID 39680406 · JAMA network open · 2024
The efficacy and safety of transcutaneous auricular vagus nerve stimulation in patients with mild cognitive impairment: A double blinded randomized clinical tri · PMID 36150665 · Brain stimulation · 2022
Noninvasive Vagus Nerve Stimulation in Postural Tachycardia Syndrome: A Randomized Clinical Trial. · PMID 37999672 · JACC. Clinical electrophysiology · 2024

Pre-registered predictions

Locked before readout.

Predictions for this study are SHA-256 locked before any readout. Pre-registration covers target engagement, primary endpoint, secondary endpoints, and the falsification criterion. The hash, prediction wording, and timestamp are available to verified clinicians and indication researchers on request.Gated

Methodology pillars used

Same stack, every indication.

M2 · Pre-Registration — SHA-256 locking before readout.
M1 · IBC Reasoning — 19-agent audit (11 core + 8 reasoning nodes).
M3 · Cross-Trial Validation — mechanism-anchored bridging across indications.
M4 · RWE Pipelines — ClinicalTrials.gov, PubMed, FDA, EDGAR feeds (the source of the numbers above).

Want the full Vagus Nerve (VNS) protocol?

The abstract above is open. Compound lists, dose escalations, SHA-256-locked prediction documents, agent-network reasoning chains, and trial design specifics are available to verified clinicians, indication researchers, and sponsors under MNDA. Contact management to begin the access request.

Contact management →