Pipeline · Specialty

Lymphedema.Pre-Clinical / Designed

Post-surgical and primary lymphedema with lymphangiogenic compound stack and mechanical-decongestion synergy. Volumetric (water-displacement) primary endpoint.

Status: Pre-Clinical / Designed
Therapeutic area: Specialty
Key: Volumetric endpoint · Post-surgical
The premise

The mechanism we're betting on.

Post-surgical and primary lymphedema with lymphangiogenic compound stack and mechanical-decongestion synergy. Volumetric (water-displacement) primary endpoint. The full mechanism map — including compound list, dose escalation, pre-specified biomarker thresholds, and the cross-walk modifiers used when re-fitting blends from related indications — is part of the gated methodology pack.Gated

RWE — real-world public landscape

What the rest of the world is doing.

Numbers below are surfaced by Atlas Bio's ClinicalTrials.gov and PubMed RWE pipelines, run against the Lymphedema indication. Counts are industry-wide trials registered on ClinicalTrials.gov, not Atlas Bio studies. Methodology →

RWE refreshed 2026-05-12
Phase I (B1/B2)
20
trials
Phase II (B3)
48
trials
Phase III (B4)
23
trials
Phase IV (B5)
19
trials
Top public trials by enrollment
NCT04844905 · Adjunctive Ivermectin Mass Drug Administration for Malaria Control · London School of Hygiene and Tropical Medi · n=24,000 · PHASE3 · UNKNOWN
NCT03676140 · Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) · Lihir Medical Centre · n=20,000 · PHASE3 · COMPLETED
NCT03570814 · Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin · London School of Hygiene and Tropical Medi · n=13,511 · PHASE4 · COMPLETED
Recent published clinical evidence
Pre-registered predictions

Locked before readout.

Predictions for this study are SHA-256 locked before any readout. Pre-registration covers target engagement, primary endpoint, secondary endpoints, and the falsification criterion. The hash, prediction wording, and timestamp are available to verified clinicians and indication researchers on request.Gated

Methodology pillars used

Same stack, every indication.

Want the full Lymphedema protocol?

The abstract above is open. Compound lists, dose escalations, SHA-256-locked prediction documents, agent-network reasoning chains, and trial design specifics are available to verified clinicians, indication researchers, and sponsors under MNDA. Contact management to begin the access request.

Contact management →