The mechanism we're betting on.
Alpha-synucleinopathy with autonomic dysfunction. Cross-walks from the PD pipeline with MSA-specific autonomic endpoints, CSF α-synuclein quantification, and tilt-table autonomic response as primary readouts. The full mechanism map — including compound list, dose escalation, pre-specified biomarker thresholds, and the cross-walk modifiers used when re-fitting blends from related indications — is part of the gated methodology pack.Gated
What the rest of the world is doing.
Numbers below are surfaced by Atlas Bio's ClinicalTrials.gov and PubMed RWE pipelines, run against the Multiple System Atrophy indication. Counts are industry-wide trials registered on ClinicalTrials.gov, not Atlas Bio studies. Methodology →
- Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. · PMID 30789229 · Brain : a journal of neurology · 2019
- Sustained effect of prasinezumab on Parkinson's disease motor progression in the open-label extension of the PASADENA trial. · PMID 39379705 · Nature medicine · 2024
- Repeated transcranial magnetic stimulation on the bilateral cerebellum to improve symptoms of ataxia with multiple system atrophy: a prospective, randomized, sh · PMID 39853449 · Neurological sciences : official journal of the Italian Neur · 2025
Locked before readout.
Predictions for this study are SHA-256 locked before any readout. Pre-registration covers target engagement, primary endpoint, secondary endpoints, and the falsification criterion. The hash, prediction wording, and timestamp are available to verified clinicians and indication researchers on request.Gated
Same stack, every indication.
- M2 · Pre-Registration — SHA-256 locking before readout.
- M1 · IBC Reasoning — 19-agent audit (11 core + 8 reasoning nodes).
- M3 · Cross-Trial Validation — mechanism-anchored bridging across indications.
- M4 · RWE Pipelines — ClinicalTrials.gov, PubMed, FDA, EDGAR feeds (the source of the numbers above).
Want the full Multiple System Atrophy protocol?
The abstract above is open. Compound lists, dose escalations, SHA-256-locked prediction documents, agent-network reasoning chains, and trial design specifics are available to verified clinicians, indication researchers, and sponsors under MNDA. Contact management to begin the access request.
Contact management →