Three feature layers.
| Version | Added | Impact |
|---|---|---|
| v2.0 | Child-Pugh granularity · substrate Gr3-shift · locoregional intervention input · refined disc formula | Closed KN-775 substrate gap; closed LEAP-002 CP-A over-prediction; enabled LEAP-012 |
| v2.1 | Efficacy module (ORR / mPFS / mOS) · risk/benefit pairing (NNT, NNH, benefit density) · auto-verdict | Single-pass safety + efficacy |
| v2.2 | Multi-combo comparator (pembro+lenva vs nivo+cabo vs pembro+axi vs atezo+bev) | Indirect comparison framework |
| v2.3 | Clinical Trial / Real-World Practice toggle · multipliers Gr3 ×1.20, fatal ×1.40, disc ×1.60, efficacy ×0.85 | Community-practice mode separates from trial mode |
Two ways to use it.
Safety analysis report Live
Calculator embedded in the safety-anchored report. Outputs Gr≥3, fatal, discontinuation, 24 AE classes, and the safety verdict (LOW / MEDIUM / HIGH / VERY HIGH).
→Efficacy analysis report Draft
Calculator embedded in the efficacy-anchored report. Outputs ORR, mPFS, mOS, CR, DCR, DoR, depth/durability scores, and the response band (LOW / MEDIUM / HIGH / EXCEPTIONAL).
→Both calculators share the same population/dose/biomarker inputs. Run them in parallel browser tabs for a full risk/benefit picture in a single patient profile.
Four validation trials, one click each.
The calculator ships with four preset scenario buttons that reproduce the published trial cohort inputs exactly:
- [CLEAR] — RCC 1L, fit ECOG 0-1, age <65, no prior cytotoxic, no substrate flags · Calibration anchor
- [KN-775] — Endometrial 2L, age 65-74, 2+ prior cytotoxic lines, pelvic RT flag on · Highest fatal-TRAE population
- [LEAP-002] — HCC 1L, age 65-74, Child-Pugh A, lenva 14 mg · Negative trial reproduction
- [LEAP-012] — HCC 1L + TACE, age 65-74, Child-Pugh A, lenva 14 mg, locoregional flag on · Locoregional rescue
Use the preset to land on a known trial cohort; then mutate inputs one at a time to see how individual modifiers (age, ECOG, substrate, biomarker) shift the prediction.
Try the calculator.
Both versions are live and open. Comments persist via Supabase to the relevant report thread.
Open safety calculator →